Here is the preset we use for posting approvals to our Review and Approval website.
This is mainly for :30 commercials.
It should output a 640x360 h.264 QuickTime with a target file size of under 10 MB.
It has some subtle changes from the stock Autodesk one, and works fairly well.
<preset label="x264" extension="mov">
<audio>
<base>-ar 44100</base>
</audio>
<video>
<base>-threads 8 -vcodec libx264 -me_method umh -coder 1 -me_range 24 -g 250
-rc_eq 'blurCplx^(1-qComp)' -keyint_min 25 -sc_threshold 40 -refs 8
-i_qfactor 0.71428572 -b_qfactor 0.76923078 -qcomp 0.6
-qmin 10 -qmax 51 -qdiff 4 -subq 9 -trellis 2
-partitions +parti4x4+partp8x8+partb8x8+parti8x8
-cmp 1 -flags2 +mixed_refs -flags2 +dct8x8 -flags2 +wpred -flags2 +bpyramid
-flags +loop -deblockalpha 0 -deblockbeta 0 -crf 17</base>
<outputW>640</outputW>
</video>
<qtfaststart>true</qtfaststart>
</preset>