Seamless integration exists between Inventor Fusion and Autodesk Simulation Mechanical. You can open a model in Inventor Fusion and send it to Autodesk Simulation Mechanical for simulation analysis. You can open the model for simulation analysis in Autodesk Simulation Mechanical, send it for editing in Inventor Fusion. After modifications are finished, you can automatically reload the updated model for analysis.
Send Inventor Fusion models to Autodesk Simulation Mechanical for analysis

The Autodesk Simulation command is available when you open any DWG file in Inventor Fusion if:
If a file format is other than DWG, you are prompted to save the file to DWG. With the model in DWG file format, Inventor Fusion launches Autodesk Simulation Mechanical and loads the model for processing inside it. Then you can assign loads and boundary conditions to geometry and perform an analysis.
Autodesk Simulation Mechanical provides a way to send the model opened for simulation to Inventor Fusion for editing purposes.
When you use the File Open dialog box to open an Inventor Fusion DWG file in Autodesk Simulation Mechanical, the model automatically loads in Inventor Fusion. If Inventor Fusion is not running in the background, then Autodesk Simulation Mechanical invokes a new instance of the application and loads the model into it.
If a file format is other than DWG, then save it to DWG in Inventor Fusion. To modify the model, in Autodesk Simulation Mechanical, on the Tools menu, click Inventor Fusion, or activate the Inventor Fusion session that loaded the model.
You can edit the model using Inventor Fusion commands. Then, on the Inventor Fusion Ribbon, Home tab, invoke the Autodesk Simulation command to send the updated model back to Autodesk Simulation Mechanical.